AstraZeneca vax linked to rare neurological disorder in India, England - Pune Mirror

Source: The Times of India

The studies, published in the peer-reviewed medical journal Annals of Neurology, describe an unusual variant of Guillain-Barre syndrome characterised by prominent facial weakness.#NEWDELHI Eleven individuals who received the AstraZeneca-Oxford Covid-19 vaccine have developed a rare neurological disorder called Guillain-Barre syndrome, clinicians in India and England have reported in two separate studies.The studies, published in the peerreviewed medical journal Annals of Neurology, describe an unusual variant of Guillain-Barre syndrome characterised by prominent facial weakness. All the eleven cases were among people who had received that vaccine 10-22 days earlier.

Seven cases were reported from a regional medical center in Kerala, India, where approximately 1.2 million people were vaccinated with the AstraZeneca Covid-19 vaccine till April 22. The cases occurred within two weeks of the first dose of vaccination."Six out of the seven patients progressed to areflexic quadriplegia and required mechanical ventilatory support," said Boby Varkey Maramattom, from the Department of Neurology, Aster Medcity, Kochi, Kerala.
"The frequency of GBS was 1.4 to 10 fold higher than that expected in this period for a population of this magnitude. In addition, the frequency of bilateral facial weakness, which typically occurs in less than 20 per cent of GBS cases, suggests a pattern associated with the vaccination," he added.Four cases were reported from Nottingham, England, in which approximately 700,000 people received the same vaccine. These were characterised by bifacial weakness with a paraesthesias variant of GBS occurring within three weeks of vaccination with the Oxford-AstraZeneca SARS-CoV-2 vaccine."This rare neurological syndrome has previously been reported in association with SARS-CoV-2 infection itself. Our cases were given either intravenous immunoglobulin, oral steroids, or no treatment," said Jonathan Rhys Evans, Department of Neurology, Nottingham University Hospitals NHS Trust, UK.
"If the link is causal it could be due to a cross-reactive immune response to the SARS-CoV-2 spike protein and components of the peripheral immune system," wrote the authors of the report from England.After black fungus, Maha gets 21 cases of the dreaded Delta Plus variantsSounding fresh alarm bells, at least 21 cases of the dreaded Delta Plus variant of Covid-19 have been reported in Maharashtra, Health Minister Rajesh Tope has said."So far, we have found 21 cases of Delta Plus variant in the state," a grim Minister Tope said, as health circles went into a tizzy to tackle the unfolding new public health challenge.The highest number of cases has been detected in the coastal districts like Ratnagiri (9), Mumbai (2) and one case each in Palghar, Thane and Sindhudurg districts, while another 7 cases detected in Jalgaon in interior northern Maharashtra.
The incidence of the Delta Plus variants comes close in the heels of the Mucormycosis or Black Fungus that the state is grappling with since the past couple of months.